Tamoxifen is a type of selective estrogen receptor modulator (SERM) indicated for the treatment of women with high risk of breast cancer. Since its approval in 1998, tamoxifen has been used to treat millions of patients diagnosed with hormone receptor positive, early stage of breast cancer after surgery to reduce the risk of recurrence. It is the first choice for treatment of premenopausal women. Tamoxifen is the generic name for Nolvadex. Tamoxifen has off-label usage for the treatment of infertility, gynecomastia, retroperitoneal fibrosis, and idiopathic sclerosing mesenteritis.
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Tamoxifen is a type of selective estrogen receptor modulator. The main pharmacologic action of Tamoxifen is to block the growth-promoting effects of estrogens on breast cancer. In bone cells, selective estrogen modulators interact with receptors the way estrogen does and strengthens bones. Tamoxifen is available in various forms such as powder, capsules, oral solution, and tablets.
For instance, 2018 Novartis received breakthrough therapy designation for Kisqali by FDA in Phase 3. Designation was based on the successful phase 3 MONALEESA-7 trials, which demonstrated significant prolonged-free survival (PFS) of Kisqali + tamoxifen (or an aromatase inhibitor). Moreover, increasing number of government and non-government organizations are investing to discover additional therapeutic applications of tamoxifen, which in turn, is expected to boost market growth. For instance, In 2017 Duchenne UK, E-Rare, Duchenne Parent Project, and Monaco Association jointly contributed US$ 766,338 for a clinical trial, which aims to study the effects of tamoxifen in treating duchenne muscular dystrophy.
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