The largest community of pharma leaders

Palliative analgesia with topical sevoflurane in cancer-related skin ulcers: a case report

A Caucasian 39-year-old male patient with a poorly-differentiated infiltrating epidermoid penile carcinoma with urethral invasion was diagnosed. The patient received concomitant adjuvant chemotherapy with radiotherapy in the palliative setting, which produced painful ulceration of tumour lesions at loco-regional level (Numerical Rate Scale, NRS=9). The patient consented for treatment with direct topical sevoflurane instillations, at initial doses of 1 mL/cm2 of ulcerated area, as per unit protocol. The local use of undiluted sevoflurane achieved a marked reduction of the pain score in both nociceptive and irruptive pains (average NRS=3 immediately post-application). This improvement was corroborated by a decline in total morphine needs, any adverse events associated with major opiates. PGI-I and CGI-I scales were used before and after treatment with topical sevoflurane to assess patient and clinician perceptions of improvement in the quality of life. The pharmacy of our hospital had the responsibility to elaborate pre-loaded syringes with sevoflurane so that the patient was instilled simply and comfortably.

http://ejhp.bmj.com/cgi/content/short/26/4/229?rss=1

Recent Articles

Knight and TherapeuticsMD Announce Health Canada Approval of BIJUVA®

MONTREAL & BOCA RATON, Fla.--(BUSINESS WIRE)--TXMD and Knight announces approval of...

Global DNA Sequencing Technologies, Markets & Companies Report 2020: Market Value for 2019 & Estimates for 2024 & 2029 – ResearchAndMarkets.com

DUBLIN--(BUSINESS WIRE)--The "DNA Sequencing - Technologies, Markets & Companies" report from...

Seattle Genetics and Genmab Present Data from Tisotumab Vedotin innovaTV 204 Pivotal Trial in Recurrent or Metastatic Cervical Cancer at ESMO Virtual Congress 2020

BOTHELL, Wash. & COPENHAGEN, Denmark--(BUSINESS WIRE)--Seattle Genetics, Inc. (Nasdaq:SGEN) and Genmab...

Heart Valve Voice US to Train Patients As Research Advisors and Advocates

WASHINGTON--(BUSINESS WIRE)--Heart Valve Voice US—a patient-advocacy organization focused on improving the...
2020 Call for Writers

Are you looking to inspire others in the pharma industry through your writing? You’re invited to submit your articles to become a Featured Writer for The Pharmaceutical Marketing Group website.